Association between single nucleotide polymorphisms of upstream transcription factor 1 (<i><scp>USF</scp>1</i>) and susceptibility to papillary thyroid cancer

Abstract

In this study, we found the SNPs of rs2516838 (mutant G alleles vs wild C alleles), rs3737787 (mutant T alleles vs wild C alleles) and rs2516839 (mutant A alleles vs wild G alleles) were significantly associated with PTC risk. Further large-scale studies with different ethnicities are still needed to validate our findings and explore the underlying mechanism of USF1 in PTC development.