Synthesis of Naturally Occurring, Conformationally Restricted Oxazole‐ and Thiazole‐Containing Di‐ and Tripeptide Mimetics

Abstract

An important step in the synthesis of heterocyclic amino acids such as 1, which can be used to modify and constrain peptide backbones, is the newly developed oxidation of dihydrooxazoles to give oxazoles with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU)/CCl4/acetonitrile/pyridine.