Two Functions, One Molecule: A Metal‐Binding and a Targeting Moiety to Combat Alzheimer's Disease

Abstract

Merging pharmacophores: Aggregation of the peptide amyloid-β (Aβ) is responsible for the development of Alzheimer's disease. Metal ions bound to Aβ can promote aggregation and oxidative stress, and can thus have a detrimental effect. Disruption of these processes with chelators, as well as targeting these chelators towards Aβ aggregates is therefore a promising strategy.