Brønsted Acid Catalyzed Enantioselective Three‐Component Reaction Involving the α Addition of Isocyanides to Imines

Abstract

That a chiral phosphoric acid is able to catalyze the three-component reaction of aldehydes, anilines, and alpha -isocyanoacetamides, leading to 2-(1-aminoalkyl)-5-aminooxazoles in excellent yields and moderate to good enantioselectivities, was reported. [on SciFinder (R)]