Endocrinology · 1982 · 44 citations · 0 references
Life SciencesEndocrinologyPhysiologyHormone BiochemistryNeuroendocrinologySteroid BiochemistryAdrenal EndocrinologyAdrenal HormonesEndocrine PhysiologyHormone ReleaseHormone SecretionNeuroendocrine PhysiologyAdrenal Steroid Secretion DynamicsAdrenocortical SecretionAdrenocorticotropic Hormone SecretionHypothalamic Hormone SecretionVasopressin BiologyVasopressin PhysiologyVasopressin RegulationVasopressin Secretion
Brattleboro rats which lack endogenous vasopressin have been used to study the role of vasopressin as a corticotropin-releasing factor. Plasma ACTH, beta-endorphin, and corticosterone were measured by RIA in male and female Long-Evans and Brattleboro rats under the following conditions: unstressed, after ether stress, after nicotine injection, and after adrenalectomy. A significant reduction in the ACTH, beta-endorphin, and corticosterone responses to the different experimental procedures was observed in the Brattleboro rats. However, in this strain of rats, a significant increase in the release of all three hormones was obtained, suggesting that vasopressin has only a synergistic role in the regulation of their secretion.