VEGF-induced endothelial cell migration requires urokinase receptor (uPAR)-dependent integrin redistribution

Abstract

The observations indicate that uPAR is an essential component of the network through which VEGF controls endothelial cell migration. uPAR is a bottleneck through which the VEGF-induced signal must be funnelled for both focused proteolytic activity at the leading edge and for redistribution of integrins.