<i>In Vitro</i>and<i>In Vivo</i>Evaluation of Carboplatin Delivery to the Eye Using Hydrogel-Iontophoresis

Abstract

Carboplatin-iontophoretic application at the above conditions does not have an obvious advantage over passive penetration due to high diffusion properties and insufficient molecular charge. Passive carboplatin diffusion from loaded hydrogels inserted in the lower cul-de-sac should be further investigated as a potential clinical treatment for intraocular retinoblastoma.