A kinetic analysis of the inhibition of FOX-4 -lactamase, a plasmid-mediated AmpC cephalosporinase, by monocyclic -lactams and carbapenems

Abstract

Monocyclic β-lactam and carbapenem antibiotics are effective mechanism-based inhibitors of FOX-4 β-lactamase, a clinically important pmAmpC, and provide stimulus for the development of new inhibitors to inactivate plasmidic and chromosomal class C β-lactamases.