Studies of Association of Variants Near the <i>HHEX</i>, <i>CDKN2A/B</i>, and <i>IGF2BP2</i> Genes With Type 2 Diabetes and Impaired Insulin Release in 10,705 Danish Subjects

Abstract

We validate that variants in the proximity of the HHEX/KIF11/IDE, CDKN2A/B, and IFG2BP2 loci associate with type 2 diabetes. Importantly, variations within the HHEX/KIF11/IDE and CDKN2A/B loci confer impaired glucose- and tolbutamide-induced insulin release in middle-aged and young healthy subjects, suggesting a role for these variants in the pathogenesis of pancreatic beta-cell dysfunction.