VERMICULINE, A NEW ANTIPROTOZOAL ANTIBIOTIC FROM PENICILLIUM VERMICULATUM

Abstract

A new crystalline antibiotic named vermiculine has been isolated from the fermentation broth of Penicillium vermiculatum DANGEARD. Vermiculine is a neutral colorless substance melting at 175-177°C with decomposition, containing only C, H and O. (λmax. 222mμ in methanol). The antibiotic inhibits growth of Trypanosoma cruzi, Leishmania braziliensis and some Grampositive bacteria.