Biomimetic Synthesis of <i>ent</i>-(−)-Azonazine and Stereochemical Reassignment of Natural Product

Abstract

The first total synthesis of ent-(-)-azonazine has been accomplished using a hypervalent iodine-mediated biomimetic oxidative cyclization to construct the highly strained core. Based on the results from the completed synthesis, both the relative and absolute configurations of natural (+)-azonazine were revised.