Familial chronic muco-cutaneous candidiasis.

Abstract

Chronic oral candidiasis has been described in association with abnormalities of the endocrine system on many occasions, both in case reports (Sutphin, Albright, and McCune, 1943), and more general reviews Chronic candidiasis has also been recorded in the familial thymic aplasia described by Nezelof (Nezelof et al, 1964), Swiss-type agammaglobulinaemia More recently deficiency of the migration inhibitory factor (MIF), where cell mediated immunity ap- pears to be partially defective, has been shown to be a feature of some patients with chronic candidiasis It has also been associ- ated with defective granulocyte function, as in chro- nic granulomatous disease (Quie et al, 1967) and myeloperoxidase deficiency (Lehrer and Cline, 1969).