Replication of association of <i>DENND1A</i> and <i>THADA</i> variants with polycystic ovary syndrome in European cohorts

Abstract

At least two of the PCOS susceptibility loci identified in the Chinese PCOS GWAS (DENND1A and THADA) are also associated with PCOS in European derived populations, and are therefore likely to be important in the aetiology of PCOS regardless of ethnicity. The analysis of the LHCGR gene was not sufficiently powered to detect modest effects.