Tumor Necrosis Factor-α −308G>A Allelic Variant Modulates Iron Accumulation in Patients with Hereditary Hemochromatosis

Abstract

TNF-alpha -308G>A allelic variant modulates iron accumulation in patients with hereditary (homozygous C282Y) hemochromatosis, but the effect of the TNF-alpha -308A allele on clinical manifestations of hemochromatosis was less accentuated than expected from the increased iron load associated with this allele.