Elevated Central Serotonin Transporter Binding Availability in Acutely Abstinent Cocaine-Dependent Patients

Abstract

These findings provide further evidence of serotonergic dysfunction during acute abstinence from chronic cocaine use. Age-related decline in brainstem serotonin transporter binding may underlie the poor response to selective serotonin reuptake inhibitor antidepressants seen in some elderly depressed patients.