Publication | Closed Access
On Ligand Design for Catalytic Outer Sphere Reactions: A Simple Asymmetric Synthesis of Vinylglycinol
117
Citations
30
References
1996
Year
Novel OrganocatalystsEnantioselective SynthesisEngineeringBiochemistryChiral PocketNatural SciencesLigand DesignOrganic ChemistryOrganometallic CatalysisCatalysisStereoselective SynthesisChemistryAsymmetric CatalysisBond RotationsSynthetic ChemistrySimple Asymmetric SynthesisBiomolecular EngineeringQuantitative Synthesis
A quantitative synthesis with an enantiomeric ratio of 99:1 has been achieved for the important building block vinylglycinol. The crucial concept lay in sculpting the chiral pocket in catalyst 1 by restricting bond rotations in its chiral-inducing ligand.
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