Benzo "Equation missing" pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice

Abstract

Altogether, these findings showed that DNA adduct levels and early gene expression changes did not fully distinguish target from non-target organs. However, mechanisms related to early changes in p53, Stat3 and Wnt/β-catenin pathways may play roles in defining BaP organotropism.