Drug‐induced <i>torsades de pointes</i>: data mining of the public version of the FDA Adverse Event Reporting System (AERS)

Abstract

Large spontaneous reporting databases represent an important source for signal detection of rare adverse drug reactions (ADR), such as TdP. The number of reports associated to donepezil, famotidine and mitoxantrone could be considered unexpected on the basis of current evidence and needs further investigations on their true TdP-liability.