Atrial Natriuretic Peptide–Mediated Inhibition of Microcirculatory Endothelial Ca ²⁺ and Permeability Response to Histamine Involves cGMP-Dependent Protein Kinase I and TRPC6 Channels

Abstract

ANP attenuates the inflammatory actions of histamine via endothelial GC-A/cGMP/cGKI signaling and inhibitory phosphorylation of TRPC6 channels. The therapeutic potential of this novel regulatory pathway is indicated by the observation that sildenafil improves systemic endothelial barrier functions by enhancing the endothelial effects of endogenous ANP.