Quality Specifications for the Determination of Copper, Zinc, and Selenium in Human Serum or Plasma: Evaluation of an Approach Based on Biological and Analytical Variation

Abstract

The proposed minimal quality specifications based on biological variation are generally slightly less stringent than those currently in use, although they do not drastically change the performance evaluation in the different schemes. These specifications are a first step in the harmonization of practices among the schemes and remain to be evaluated.