GENETIC ANALYSIS OF THE HISTIDINE OPERON IN <i>ESCHERICHIA COLI</i> K12

Abstract

I N Salmonella typhimurium a cluster of nine genes, behaving as a single operon (AMES and GARRY 1959) specify the enzymes which carry out the ten reactions involved in the biosynthesis of histidine; one of the nine enzymes is bifunctional (LOPER, GRABNAR, STAHL, HARTMAN and HARTMAN 1964). The histidine operon is contained in a linear segment of deoxyribonucleic acid (DNA) estimated by AMES, GOLDBERGER, HARTMAN, Fifteen cistrons have been sequenced and their enzyme products identified.