Ambient Temperature Nitrogen-Directed Difluoroalkynylborane Carboni−Lindsey Cycloaddition Reactions

Abstract

The in situ generation of alkynyldifluoroboranes in the presence of N-heterocycle substituted tetrazines provides a convenient and direct method for the synthesis of pyridazine difluoroboranes. The reactions proceed in 10 min under ambient conditions and provide the opportunity to assemble unsymmetrical products with complete regiocontrol.