Concepedia

G Protein–Coupled Receptor Kinase 2 Plays a Relevant Role in Insulin Resistance and Obesity

Lucía García‐Guerra, Iria Nieto-Vázquez, Rocío Vila‐Bedmar, María Jurado-Pueyo, Guillermo Zalba, Cristina Murga, Sonia Fernández‐Veledo, Federico Mayor, Margarita Lorenzo

Diabetes · 2010 · 92 citations · 33 references

DOI Full text

Open access

Abstract

Overall, our data identify GRK2 as an important negative regulator of insulin effects, key to the etiopathogenesis of insulin resistance and obesity, which uncovers this protein as a potential therapeutic target in the treatment of these disorders.

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