Concepedia

Increased Whole-Body and Sustained Liver Cortisol Regeneration by 11β-Hydroxysteroid Dehydrogenase Type 1 in Obese Men With Type 2 Diabetes Provides a Target for Enzyme Inhibition

Roland H. Stimson, Ruth Andrew, Norma C. McAvoy, Dhiraj Tripathi, Peter Hayes, Brian R. Walker

Diabetes · 2011 · 63 citations · 42 references

DOIFull text

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Abstract

Whole-body 11β-HSD1 activity is increased in obese men with type 2 diabetes, whereas liver 11β-HSD1 activity is sustained, unlike in euglycemic obesity. This supports the concept that inhibitors of 11β-HSD1 are likely to be most effective in obese type 2 diabetic subjects.

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