Haemoglobin Sogn (β₁₄ Arginine) A New Haemoglobin Variant

Abstract

Among 3,000 Norwegian individuals two haemoglobin variants were found. One was a Haemoglobin D Punjab. The other was a new variant, Haemoglobin Sogn, in which leucine is replaced by arginine at the internally sited residue 14 of the β chain. The haemoglobin variant shows a slight heat instability. Heterozygotes for Haemoglobin Sogn show a small amount of free α chains in their haemolysates, but no Heinz bodies are present in their erythrocytes and they are clinically healthy.