Organopentafluorosilicates: Reagents for rapid and efficient incorporation of NO‐carrier‐added radiobromine and radioiodine

Abstract

Abstract An investigation exploring the utility of organopentafluorosilicates as intermediates for the site specific incorporation of no‐carrier‐added radiobromine or radioiodine into organic molecules was carried out. Some simple alkyl‐ and arylpentafluorosilicates were synthesized and reacted with in situ generated [ 77 Br]BrCl and 131 I)ICl. The radiohalogenations of aryl‐ and primary alkylpentafluorosilicates were found to be complete within 10 minutes at room temperature, with radiochemical yields of 74‐96%. Radiohalogenations of a secondary alkylpentafluorosilicate, cyclohexylSiF 5 K 2 , gave lower radiochemical yields and required higher reaction temperatures.