Iron‐Catalyzed N‐Arylation of Nitrogen Nucleophiles

Abstract

Easy does it! A simple procedure for the N-arylation of nitrogen-containing heterocycles and primary amides relies on a catalyst formed in situ from inexpensive and environmentally benign FeCl3 and a diamine ligand. The cross-coupling reaction with aryl halides provides N-arylated compounds in high yields (see scheme; R=H, Cl, Me, OMe, CO2Et, F, CF3).