Hydrocortisone Affects the Expression of Matrix Metalloproteinases (MMP‐1, ‐2, ‐3, ‐7, and ‐11) and Tissue Inhibitor of Matrix Metalloproteinases (TIMP‐1) in Human Gingival Fibroblasts

Abstract

Hydrocortisone produced a dose-dependent regulation of MMP and TIMP expression. The higher hydrocortisone concentration significantly upregulated expression of MMP-1, -2, -7, and -11 and TIMP-1 in human gingival fibroblasts, which may constitute a mechanism underlying the increased periodontal breakdown associated with psychosocial stress status.