Publication | Open Access
Selective photosensitization through an AND logic response: optimization of the pH and glutathione response of activatable photosensitizers
65
Citations
33
References
2015
Year
EngineeringAnd Logic ResponseSynthetic PhotochemistryOptogeneticsNanomedicineSelective PhotosensitizationPka ValuesPhototoxicityPhotocatalysisPh RangePhotosensitizersPhotosynthesisHealth SciencesPhotochemistryBiochemistryPhotodynamic TherapyMechanistic PhotochemistryPharmacologySupramolecular PhotochemistryBiomolecular EngineeringGlutathione ResponseGsh Responsive PhotosensitizersPhotoprotection
A series of pH and GSH responsive photosensitizers were designed and synthesized. pKa values were optimized by adjusting the inductive contribution of substituents to reach a pH range (6.0-7.4) relevant to the tumour microenvironment. pH-Activatable behaviour and redox mediated release of the quencher from the PS by GSH allow the construction of an AND logic operator for selective photodynamic action in aqueous solutions.
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