Monitoring Breast Tumor Lung Metastasis by U-SPECT-II/CT with an Integrin α_vβ₃-Targeted Radiotracer^99mTc-3P-RGD₂

Abstract

This study clearly demonstrated that (99m)Tc-3P-RGD(2) is an excellent radiotracer for noninvasive imaging of metastatic breast tumors in the lungs, mediastinal lymph nodes and muscles. (99m)Tc-3P-RGD(2) SPECT/CT is an outstanding platform for monitoring the progression of breast cancer lung metastases, semi-quantification of breast tumor load in the lungs and delineation of tumor necrosis in small animals.