Fcγ receptors directly mediate cartilage, but not bone, destruction in murine antigen‐induced arthritis: Uncoupling of cartilage damage from bone erosion and joint inflammation

Abstract

Activating FcgammaR are crucial in mediating cartilage destruction independently of joint inflammation. In contrast, FcgammaR are not directly involved in bone erosion. Indirectly, FcgammaR drive bone destruction by regulating joint inflammation.