Microbial conversion of .EPSILON.-pyrromycinone and .EPSILON.-isorhodomycinone to 1-hydroxy-13-dihydrodaunomycin and n-formyl-1-hydroxy-13-dihydrodaunomycin and their bioactivities.

Abstract

New anthracycline antibiotics, 1-hydroxy-13-dihydrodaunomycin and N-formyl-1-hydroxy-13-dihydrodaunomycin were biosynthesized by a blocked mutant of Streptomyces coeruleorubidus ME130-A4 from epsilon-pyrromycinone or epsilon-isorhodomycinone.