Preparation of fenofibrate nanosuspension and study of its pharmacokinetic behavior in rats

Abstract

The dissolution rate of fenofibrate nanosuspension was increased obviously, and the product was evaluated by pharmacokinetic characteristic in rats. The AUC(0-36 h) and C(max) of nanosuspensions were increased when compared with the reference formulations. No significant differences were found between the two nanosuspensions A and B, of which the mean particle sizes were 356 and 194 nm, respectively. Therefore, nanosuspensions may be a suitable delivery system to improve the bioavailability of those drugs with poor water solubility.