Performance of Common Genetic Variants in Breast-Cancer Risk Models

Abstract

The inclusion of newly discovered genetic factors modestly improved the performance of risk models for breast cancer. The level of predicted breast-cancer risk among most women changed little after the addition of currently available genetic information.

References

Page 1

	Year	Citations
Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyond Michael J. Pencina, Ralph B. D' Agostino, Ralph B. D' Agostino, Statistics in Medicine	2007	6.2K
Projecting Individualized Probabilities of Developing Breast Cancer for White Females Who Are Being Examined Annually M. H. Gail, Louise A. Brinton, David P. Byar, JNCI Journal of the National Cancer Institute Epidemiology Of CancerCancer RegistrationSocial Determinants Of HealthCancer Risk FactorsCancer Disparity	1989	3.3K
Genome-wide association study identifies novel breast cancer susceptibility loci Douglas F. Easton, Karen A. Pooley, Alison M. Dunning, Nature Genome-wide Association StudyGeneticsGenetic EpidemiologyCancer GenomicsBreast Cancer	2007	2.3K
Screening for Breast Cancer: U.S. Preventive Services Task Force Recommendation Statement Albert L. Siu Annals of Internal Medicine	2016	2.1K
Screening for Breast Cancer: U.S. Preventive Services Task Force Recommendation Statement Annals of Internal Medicine	2009	1.6K
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer David J. Hunter, Peter Kraft, Kevin B. Jacobs, Nature Genetics Genome-wide Association StudyBreast OncologyCancer RiskMedicineGenetics	2007	1.5K
Clinical Risk Factors, DNA Variants, and the Development of Type 2 Diabetes Valeriya Lyssenko, Anna Jonsson, Peter Almgren, New England Journal of Medicine	2008	933
One Degree of Freedom for Non-Additivity John W. Tukey Biometrics EngineeringUncertainty QuantificationError ContributionModel TheoryBiostatistics	1949	903
Validation Studies for Models Projecting the Risk of Invasive and Total Breast Cancer Incidence Joseph P. Costantino, Mitchell H. Gail, D. Pee, JNCI Journal of the National Cancer Institute	1999	752
Polymorphisms Associated with Cholesterol and Risk of Cardiovascular Events Sekar Kathiresan, Olle Melander, Dragi Anevski, New England Journal of Medicine	2008	711

Page 1