Hyperbaric Oxygen as an Adjunct in Zygomycosis: Randomized Controlled Trial in a Murine Model

Diana Barratt, Keith Van Meter, Philip Asmar, Terry Nolan, Chris G Trahan, Lisardo García-Covarrubias, Stephen E. Metzinger

Antimicrobial Agents and Chemotherapy · 2001 · 47 citations · 10 references

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Abstract

Zygomycosis was induced by injecting CD-1 mice with 5 mg of intraperitoneal deferoxamine and then 10(6) CFU of intravenous and intrasinus Rhizopus arrhizus. The addition of hyperbaric oxygen (2.0 atm absolute twice daily) to amphotericin B did not improve survival over that achieved with amphotericin B and placebo air treatments.

References

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