An immunohistochemical study of chromogranin A and human epidermal growth factor‐2 expression using initial prostate biopsy specimens from patients with bone metastatic prostate cancer

Abstract

NE cell differentiation of the primary tumour in patients with bone metastatic prostate cancer does not reflect the prognosis, whereas HER-2 overexpression is a prognostic factor for an unfavourable outcome. These results suggest that NE cell differentiation is not induced by HER-2.