Quantification of Human and Rodent Brown Adipose Tissue Function Using^99mTc-Methoxyisobutylisonitrile SPECT/CT and¹⁸F-FDG PET/CT

Abstract

Pharmacologic activation of BAT requires increased blood flow to deliver glucose and oxygen for thermogenesis. However, the glucose consumption far exceeds the vascular response. These findings demonstrate that activated BAT increases glucose uptake beyond what might occur by increased blood flow alone and suggest that activated BAT likely uses glucose for nonthermogenic purposes.