Pharmacokinetics of Methylphenidate in Preschoolers with Attention-Deficit/Hyperactivity Disorder

Abstract

In this sample, age significantly affected absorption and metabolism of MPH, so that preschool children had greater exposure than school-aged children to the same weight-adjusted dose. These data suggest additional studies should be performed to characterize age-related differences in PK properties of MPH that may inform practitioners about dosing strategies based on the age and size of children being treated.