Concepedia

Effective Inhibition of the Epidermal Growth Factor/Epidermal Growth Factor Receptor Binding by Anti–Epidermal Growth Factor Antibodies Is Related to Better Survival in Advanced Non–Small-Cell Lung Cancer Patients Treated with the Epidermal Growth Factor Cancer Vaccine

Beatriz García Verdecia, Elia Neninger, Ana de la Torre, I. Leonard, Rocío Martínez, Carmen Viada, Gisela González, Zaima Mazorra, Agustín Lage, Tania Crombet

Clinical Cancer Research · 2008 · 117 citations · 13 references

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Abstract

Immunization with the EGF vaccine induced neutralizing anti-EGF antibodies capable of inhibiting EGFR phosphorylation. There was a significant positive correlation between antibody titers, EGF/EGFR binding inhibition, immunodominance of anti-EGF antibodies, and survival in advanced NSCLC patients.

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