An Amine‐Promoted Aziridination of Chalcones

Abstract

Without protection: α-Keto aziridines have been formed in a novel amine-promoted direct aziridination of chalcones using an aminimide generated in situ from a tertiary amine and O-mesitylenesulfonylhydroxylamine (MSH) in the presence of base (see scheme). The aziridination proceeds well using a catalytic amount of the tertiary amine. Furthermore, nonracemic aziridines are obtained using a chiral amine. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z602586_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.