Chiral Counteranion Strategy for Asymmetric Oxidative C(sp³)H/C(sp³)H Coupling: Enantioselective α‐Allylation of Aldehydes with Terminal Alkenes

Abstract

The first enantioselective α-allylation of aldehydes with terminal alkenes has been realized by combining asymmetric counteranion catalysis and palladium-catalyzed allylic C-H activation. This method can tolerate a wide scope of α-branched aromatic aldehydes and terminal alkenes, thus affording allylation products in high yields and with good to excellent levels of enantioselectivity. Importantly, the findings suggest a new strategy for the future creation of enantioselective C-H/C-H coupling reactions.