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Lack of effect of GR43175 on peripheral arteries in man.
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1989
Year
HypertensionVascular DiseaseBlood PressureThrombosisVascular SurgeryApplied PhysiologyMicrovascular DysfunctionHealth SciencesCardiovascular ImagingAntihypertensive TherapyVascular PharmacologyMale VolunteersVascular BiologyPeripheral Artery DiseasePeripheral Vascular DiseaseCardiovascular DiseasePhysiologyPeripheral ArteriesPlacebo-controlled Crossover StudyMedicineCardiovascular GeneticsAnesthesiologyVascular Medicine
In a double-blind, placebo-controlled crossover study in eight male volunteers, toe-arm systolic gradients, measured with strain-gauge plethysmography, were measured for 4 h after 2 mg intravenous GR43175 or placebo. No changes were observed, indicating that GR43175 is without significant vasoconstrictor effect on peripheral arteries in man.