The consequences of translational and rotational entropy lost by small molecules on binding to proteins

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Suzanne B. Shuker, Philip J. Hajduk, Robert Meadows et al. · Science · 1996 · 2K citations

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Empirical scoring functions: I. The development of a fast empirical scoring function to estimate the binding affinity of ligands in receptor complexes

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Pharmacy, Bioinformatics, Medicinal Chemistry +12

Avidin

N. Michael Green · Advances in protein chemistry · 1975 · 1.5K citations

Entropic Contributions to Rate Accelerations in Enzymic and Intramolecular Reactions and the Chelate Effect

Michael I. Page, William P. Jencks · Proceedings of the National Academy of Sciences · 1971 · 1K citations · Full text

Natural Sciences, Biochemistry, Chemistry +11

The development of a simple empirical scoring function to estimate the binding constant for a protein-ligand complex of known three-dimensional structure

Hans-Joachim B�hm · Journal of Computer-Aided Molecular Design · 1994 · 1K citations

Life Sciences, Biophysics, Medicinal Chemistry +16