Phosphodiesterase Type 3A Regulates Basal Myocardial Contractility Through Interacting With Sarcoplasmic Reticulum Calcium ATPase Type 2a Signaling Complexes in Mouse Heart - Concepedia

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Phosphodiesterase Type 3A Regulates Basal Myocardial Contractility Through Interacting With Sarcoplasmic Reticulum Calcium ATPase Type 2a Signaling Complexes in Mouse Heart

DOI Full Paper Access

130

Citations

28

References

2012

Year

Sanja Beca, Faiyaz Ahmad, Weixing Shen, Jie Liu, Samy Makary, Nazari Polidovitch, Junhui Sun, Steven Hockman, Youn Wook Chung, Matthew A. Movsesian,

Circulation Research

Abstract

Our data support the conclusion that PDE3A is the primary PDE3 isozyme modulating basal contractility and SR Ca(2+) content by regulating cAMP in microdomains containing macromolecular complexes of SR calcium ATPase type 2a-phospholamban-PDE3A.

References

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