Probing the Modulation of Acute Ethanol Intoxication by Pharmacological Manipulation of the <scp>NMDAR</scp> Glycine Co‐Agonist Site

Abstract

Glycine(B) site activation failed to produce the hypothesized reduction in EtOH intoxication across a range of measures and genetic strains, but blockade of the glycine(B) site potentiated EtOH intoxication. These data suggest endogenous activity at the glycine(B) opposes EtOH intoxication, but it may be difficult to pharmacologically augment this action, at least in nondependent subjects, perhaps because of physiological saturation of the glycine(B) site.