Neurology · 2001 · 347 citations · 6 references
MedicinePharmacologyPharmacotherapyClinical PharmacologyNeuropharmacologyPharmacodynamicsCannabinoid PharmacologyDrug-induced Movement DisordersGabaergic PharmacologyGabaergic SignalingParkinson DiseaseParkinsonian DisordersCannabinoid AgonistsCannabinoid Effects On Motor FunctionCannabinoid Receptor ModulationCannabinoid Receptor PharmacologyDyskinesia ReductionGlobus Pallidus Internal SegmentParkinson's Disease PharmacotherapyParkinson’s Disease Pharmacotherapy
The lateral segment of the globus pallidus (GPl) is thought to be overactive in levodopa-induced dyskinesia in PD. Stimulation of cannabinoid receptors in the GPl reduces gamma-aminobutyric acid (GABA) reuptake and enhances GABA transmission and may thus alleviate dyskinesia. In a randomized, double-blind, placebo-controlled, crossover trial (n = 7), the authors demonstrate that the cannabinoid receptor agonist nabilone significantly reduces levodopa-induced dyskinesia in PD.
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Core assessment program for intracerebral transplantations (CAPIT)
J. William Langston, Håkan Widner, Christopher G. Goetz et al. · Movement Disorders · 1992 · 1K citations
Critical analysis of the disability in Parkinson's disease.
David D. Webster · PubMed · 1968 · 490 citations
Medicine, Neurology, Neuroscience +12