Science · 1999 · 967 citations · 34 references
Life SciencesGeneticsMicrobiologyDna RepairGenomicsMicrobial GeneticsDna DamageDna Double-strand Break RepairMicrobial Genome StructurePlasmid BiologyPlasmid GeneticsPlasmid GenomicsBacterial Genome StructureDna Repair MechanismsGenetic RedundancyOxidative Dna DamageRadiation Resistance MechanismsRadiation-induced Dna DamageRadiation-resistant MicrobiologyRepair Of Ionizing Radiation-induced Breaks
The complete genome sequence of the radiation-resistant bacterium Deinococcus radiodurans R1 is composed of two chromosomes (2,648,638 and 412,348 base pairs), a megaplasmid (177,466 base pairs), and a small plasmid (45,704 base pairs), yielding a total genome of 3,284, 156 base pairs. Multiple components distributed on the chromosomes and megaplasmid that contribute to the ability of D. radiodurans to survive under conditions of starvation, oxidative stress, and high amounts of DNA damage were identified. Deinococcus radiodurans represents an organism in which all systems for DNA repair, DNA damage export, desiccation and starvation recovery, and genetic redundancy are present in one cell.
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Microbial gene identification using interpolated Markov models
Steven L. Salzberg, Arthur L. Delcher, Simon Kasif et al. · Nucleic Acids Research · 1998 · 997 citations · Full text