Acta Biochimica et Biophysica Sinica · 2005 · 22 citations · 15 references
MedicineMolecular BiologyOncologyGene ExpressionMetastasisMolecular OncologyCancer BiomarkersCancer GenomicsCancer Molecular PathologyMalignant NeoplasmsMolecular Tumor ProfilingNasopharyngeal CancerAutomatic AnnotationCancer Metastasis BiomarkersComparative Cancer Gene Expression ProfilesComparative Tumorigenicity ProfilingMicroarray AnalysisOncogene Expression AnalysisTumor Suppressor Gene AnalysisTumor-specific Biomarkers
In gene expression profiling, nasopharyngeal carcinoma (NPC) 5-8F cells differ from 6-10B cells in terms of their high tumorigenicity and metastatic ability. Differentially expressed genes from the two cell types were analyzed by combining with MILANO (the automatic custom annotation of microarray results which is based on all the available published work in PubMed). The results showed that five genes, including CTSD, P63, CSE1L, BPAG1 and EGR1, have been studied or mentioned in published work on NPC. Subsequently, we reevaluated the roles of these genes in the pathogenesis of NPC by combining the data of gene chips from NPCs versus NPs and pooled cells from 5-8F, 6-10B and CNE2 versus NPs. The results suggested that the roles of BPAG1 and EGR1 are possibly different from those reported in previous NPC studies. These five genes are likely to be involved in the proliferation, apoptosis, invasion and metastasis of NPC. A reexploration of the genes will further define their roles in the pathogenesis of NPC.
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Genome‐wide profiling of oral squamous cell carcinoma
Yann‐Jang Chen, Shu‐Chun Lin, Tsai Kao et al. · The Journal of Pathology · 2004 · 154 citations