Highly Enantioselective Co‐Catalytic Direct Aldol Reactions by Combination of Hydrogen‐Bond Donating and Acyclic Amino Acid Catalysts

Abstract

Abstract Highly enantioselective co‐catalytic direct aldol reactions by a combination of simple hydrophobic acyclic amino acid and hydrogen‐bond donating catalysts are presented. The corresponding aldol products are formed in high yields with high regio‐, diastereo‐ ( anti or syn ) and enantioselectivity (up to 99.5:0.5 er ). The catalyst loadings can be decreased to as little as 2 mol%.