High Levels of Costimulatory Receptors OX40 and 4-1BB Characterize CD4 ⁺ CD28 ^null T Cells in Patients With Acute Coronary Syndrome

Abstract

Costimulatory pathways are altered in CD4(+)CD28(null) T cells in ACS. We show that the inflammatory and cytotoxic function of CD4(+)CD28(null) T cells can be inhibited by blocking OX40 and 4-1BB costimulatory receptors. Modulation of costimulatory receptors may allow specific targeting of this cell subset and may improve the survival of ACS patients.